Galactose-Clicked Curcumin-Mediated Reversal of Meropenem Resistance among Klebsiella pneumoniae by Targeting Its Carbapenemases and the AcrAB-TolC Efflux System

In over eighty years, despite successive antibiotics discoveries, the rapid advent of multidrug resistance among bacterial pathogens has jolted our misapprehension success them. Resistance is spreading faster than discovery new antibiotics/antimicrobials. Therefore, search for better antimicrobials/additives becomes prudent. A water-soluble curcumin derivative (Curaq) was synthesised, employing a Cu (I) catalysed 1, 3-cyclo addition reaction; it been evaluated as potential treatment multidrug-resistant isolates and an antibiotic adjuvant meropenem against hypervirulent Klebsiella pneumoniae isolates. We also investigated its solubility effect carbapenemase activity. Additionally, we impact on AcrAB-TolC system. found that Curaq inhibited growth at minimal concentration 16 µg/mL; 32 µg/mL concentration, killed completely. Only nine (9.4%) were sensitive to meropenem; however, after synergising with (8 µg/mL), 85 (88.54%) hvKP became drug. The efflux system 1 by disrupting membrane causing depolarisation. kinetic parameters obtained indicated promise inhibitor. These results suggest can be excellent drug candidate broad-spectrum antibacterial anti-efflux agent.